Jadon Sancho has been sidelined for the next two weeks with a calf injury, according to reports from Germany.
The Manchester United winger was forced off in the second half of last week's Champions League game against Benfica and is now expected to be out of action until at least mid-March.
Sancho's absence will be a blow for the Red Devils, who were already struggling without his pace and creativity in attack.
However, there is still hope that he may be able to return to full fitness ahead of the Premier League restart on April 12.
In the meantime, Ole Gunnar Solskjaer will have to look elsewhere for attacking options in the short term.
Borussia Dortmund, where Sancho is currently on loan from Manchester United, have also suffered a major setback with the news that their star midfielder Jude Bellingham is set to undergo surgery on his knee.
The 18-year-old has been out since January with a cruciate ligament injury and is expected to miss up to six months.
This is a huge disappointment for Dortmund, who were hoping to use Bellingham's talents to challenge for the Bundesliga title this season.
Despite these setbacks, both teams will be looking to bounce back from recent defeats and secure important victories in the coming weeks.